Prem (Salman Khan) is a Love Guru who solves the love issues of his clients. He meets Bhaskar Diwakar Chaudhary (Govinda) who comes to Prem for help in his love life. Bhaskar loves his boss Priya Jaisingh (Katrina Kaif) but is unable to express his love to her as she is the daughter of a wealthy businessman. Prem initially refuses to help Bhaskar and goes to Phuket, Thailand. Bhaskar follows him there and convinces him to help.

After returning from Thailand, Prem meets Naina (Lara Dutta), a photo journalist who was running from some gangsters led by Chhota Don (Rajpal Yadav), who mimicks Shahrukh Khan in Don. Prem saves her and falls in love with her. Meanwhile, he starts teaching Bhaskar how to impress Priya. But Bhaskar uses his own simplicity and nonsense acts to impress Priya. Priya finally falls in love with Bhaskar but does not disclose it to him.

Prem comes to know from Bhaskar that Priya is getting married to someone according to her father's will. They both come to Priya's wedding ceremony with Naina, and Priya's father is convinced by Bhaskar's acts. Priya now gets ready to marry Bhaskar.

Meanwhile, a spoiled brat named Neil comes to Prem for love help and he asks Prem to convince a girl to have a one-night stand. Prem gets angry with Neil and tells him that he does not help people with such bad intentions. Neil somehow manages to get his one-night stand and then ditches her, telling her the love guru gave him advice to do so. Unfortunately, the girl turns out to be Naina's friend Nikki. Naina then sets out to expose the Love Guru and finds out that it is Prem. Naina hates Prem for what she thought he did to her friend and publishes a front page article claiming that Prem can set anyone up with the girl they want using the Priya/Bhaskar relationship as an example.

Prem thinks that Bhaskar may commit suicide without Priya and goes to her to tell her what really happened. Priya realizes that all the things she liked about Bhaskar are what Prem wanted Bhaskar to hide from her and Priya is ready to take Bhaskar back. Prem makes up with Naina by making her hear the truth about him not helping Neil, and they get back together. On both couples' honeymoon night, Bhaskar again asks Prem for help but this time they both get mingled with their respective wives.

Lovely Singh (Salman Khan) is assigned as Divya's (Kareena Kapoor) bodyguard to protect her from goons hunting her to take revenge against her father, a kind and successful politician. Lovely is very devoted to his duties—but irritates Divya by following her everywhere. Divya and her friend Maya (Hazel Keech) call Lovely; with Divya pretending to be a girl, Chhaya madly in love with Lovely, hoping this will distract him from his work.

Initially hesitant, Lovely gradually starts loving the mysterious Chhaya and looks forward to her calls, but doesn't realize that it is actually Divya. Meanwhile, Lovely protects Divya on many occasions from the attacks of Ranjan Mahatre and his goons. Soon, Divya too falls in love with Lovely but is scared to reveal her identity, due to Lovely's immense devotion and loyalty toward his duties and her father. Divya, as Chhaya, later tells Lovely to run away with her and meet her at a railway station. Her father, Sartaj, begins suspecting that Lovely and Divya are in love and they might elope so he sends his men to kill Lovely. Divya convinces her father that Lovely's lover is someone else who is waiting for him at the railway station. Sensing that Lovely might be heartbroken if he does not meet his Chhaya, Divya sends Maya to tell Lovely her true identity. However, when Lovely sees Maya running toward him, he believes she is Chhaya. Maya tries to tell him that Divya is Chhaya, but sees one of Sartaj's men in the compartment, waiting for her to answer Lovely. She tells Lovely that she is Chhaya. Divya calls Maya but Maya gets on the train with Lovely and throws her phone away instead of returning to her friend.

Lovely and Maya marry and have a son but Maya unexpectedly dies early from a disease. Several years later, Sartaj invites Lovely and his son to his house and apologizes for his behaviour. Lovely believed that Divya was happily married in London so he is shocked to see her still living in the house, unmarried. His son, who knows of his mother's betrayal from a diary Maya had left him, explaining what she had done and that her early death was the punishment for her betrayal of her friend, grows close to Divya and apologizes to her on his mother's behalf.

On their last day of their visit, Lovely's son asks Divya to accompany him as his mother. Infuriated, Lovely tells his son to apologize but Sartaj tells Lovely that he feels the same and requests him to take Divya with him. Lovely accepts. At the railway station, Lovely's son secretly throws away Maya's diary into the trash, having completed his mission. However, Lovely sees him and takes the diary from the trash. Upon reading it, he discovers that Divya was his actual love, Chhaya, and that Maya had lied. He calls Divya on her mobile and addresses her as Chhaya. Divya is overwhelmed with joy, realizing Lovely finally knows the truth, and the couple are united.

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